| 1922 | Clinical use of insulin for diabetes – Dr. Frederick Banting and Dr. Charles Best |
| 1935 | Clinical use of Heparin as a blood thinner – Dr. Gordon Murray |
| 1946 | Design and use of North America’s first artificial kidney – Dr. Gordan Murray |
| 1950 | Use of first regulated cardiac pacemaker – Dr. Bill Bigelow |
| 1950 | Use of total body cooling as a method of making heart surgery safer – Dr. Bill Bigelow |
| 1950s | Introduction of lumpectomy for breast cancer – Dr. Vera Peters |
| 1950s | Use of radiation to cure Hodgkin’s disease – Dr. Vera Peters |
| 1951 | Use of cobalt radiotherapy units for cancer – Dr. Harold Johns |
| 1955 | Human heart valve transplant – Dr. Gordan Murray |
| 1960s | Coronary Care Unit – Dr. Robert MacMillan and Dr. Ken Brown |
| 1961 | Discovery of blood forming stem cells enabling bone marrow transplants – Dr. Ernest McCulloch and Dr James Till |
| 1965 | Developed prototype aneurysm clip – Dr. William Lougheed |
| 1973 | Use of pulmonary testing called flow volume loop to diagnose small airway disease (e.g., asthma and COPD) – Dr. Noe Zamel |
| 1975 | Development of software used worldwide for 20 years to control radiation therapy – Dr. Jack Cunningham |
| 1976 | Identification of P-glycoprotein as a major cause of cancer drug resistance – Dr. Victor Ling |
| 1977 | Developed a technique for Peritoneal Dialysis that made it possible on a large scale – Dr. Dimitri Oreopoulos |
| 1978 | Discovery of reversibility of brain damage from alcohol with abstinence – Dr. Peter Carlen |
| 1983 | Successful single lung transplant – Dr. Joel Cooper |
| 1984 | First cloning of the T-cell receptor genes, significant in the field of immunology – Dr. Tak Mak |
| 1985 | Reconstruction of the mitral annulus (the supporting structure for cardiac valves) – Dr. Tirone David |
| 1986 | Successful double lung transplant – Dr. Joel Cooper |
| 1986 | Use of a patch technique to repair ruptures of the heart wall following a heart attack – Dr. Tirone David |
| 1987 | Development of a new pig valve to replace the diseased aortic valve – Dr. Tirone David & Dr. Chris Feindel |
| 1988 | Mapping and surgical correction of cardiac rhythm disorders – Dr. Lynda Mickleborough and Dr. Eugene Downar |
| 1988 | Operation to spare the aortic valve in patients with aortic aneurysm – Dr. Tirone David and Dr. Chris Feindel |
| 1989 | Treatment of sleep apnea in patients with heart failure by mechanical assist device (CPAP) reduces morbidity and mortality – Dr. Doug Bradley and Dr. John Floras |
| 1990s | Identification of genes responsible for hereditary blindness, Alzheimer’s, Lou Gehrig’s and Huntington’s disease – Dr. Peter St. George Hyslop |
| 1991 | Reconstruction of the inflow and outflow tracts of the heart using two conduits – Dr. Tirone David |
| 1992 | Developed a novel experimental technique that employs chemical substances to prevent or treat brain damage from stroke or trauma by regulating cell calcium levels – Dr. Chris Wallace |
| 1994 | Showing genetic predisposition to developing Reflex Sympathetic Dystrophy – Dr. Angela Mailis |
| 1996 | Awake craniotomy with same day discharge for brain tumour removal using image guided approach – Dr. Mark Bernstein |
| 1996 | Chemotherapy treatment for hormone-resistant prostate cancer – Dr. Ian Tannock and Dr. Malcom Moore |
| 1996 | Description of a substance that causes intestines to regrow (GLP-2) – Dr. Dan Drucker |
| 1996 | Transplantation of heart cells into damaged and scarred heart muscel to improve heart function – Dr. Ren-Ke Li and Dr. Richard Weisel |
| 1999 | Identifying the individual brain cells that control pain – Dr. Karen Davis and Dr. Andres Lozano |
| 2000 | Identification of novel T regulatory cells to induce tolerance in transplant patients – Dr. Li Zhang |
| 2000 | Identification of the novel immune molecule CD 200 to modify host immune response in transplantation – Dr. Reg Gorczynski |
| 2001 | Determining the utility of 2 hour post dose cyclosporine levels to improve clinical outcomes in transplantation – Dr. Gary Levy and Dr. Ed Cole |
| 2001 | Development of new pig valve and aorta to replace the diseased aortic root – Dr. Tirone David |
| 2001 | Development of the “Marshall Score” for classifying Multiple Organ Dysfunction Syndrome – Dr. John Marshall |
| 2001 | Discovery that a protein called Interleukin 13 fuels the growth of Hodgkin’s lymphoma – Dr. Tak Mak |
| 2002 | Deduction of the structure of a molecular complex in the brain involved in many functions including memory and learning – Dr. Mitsu Ikura |
| 2002 | Demonstrating that dense breast tissue, a major risk factor in breast cancer, is mainly determined by genetic factors – Dr. Norman Boyd. |
| 2002 | Description of the role of IRAK-4, an immune molecule, critical for first-line defense against infections – Dr. Wen-Chen Yeh, Dr. Tak Mak and Dr. Pam Ohashi |
| 2002 | Discovery that fragile X syndrome (most common inherited cause of mental retardation) is related to glutamate in the brain – Dr. Peter Carlen |
| 2002 | Identification of protein that triggers autoimmune response in Sjögren’s syndrome, as well as a vaccine to treat the condition – Dr. Arthur Bookman |
| 2002 | Identifying gene clusters using microarray technology that are involved in lung cancer – Drs. Denis Wigle, Igor Jurisica, Jim Woodgett, Shaf Keshavjee, Gail Darling, Frances Shepherd and Ming Tsao |
| 2002 | Proof of efficacy of new treatment for HIV infection – Dr. Sharon Walmsley |
| 2003 | Developing method for detecting gene mutations that enhance care for families with retinoblastoma – Dr. Brenda Gallie |